Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status.
| Autor: | Azieva AM; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.; Kurchatov Institute National Research Center, Moscow, 123182, Russia., Sheinov AA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia., Galkin FA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia., Georgieva SG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Soshnikova NV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia. so2615nat@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2018 Mar; Vol. 479 (1), pp. 66-68. Date of Electronic Publication: 2018 May 19. |
| DOI: | 10.1134/S1607672918020035 |
| Abstrakt: | It was found that, in the differentiated cells of mouse brain, the level of core (Brg1 and BAF155) and specific (BRD7, BAF180, and PHF10) subunits of the chromatin-remodeling complex PBAF is reduced compared to the undifferentiated proliferating cells. Phosphorylation of PBAF complex subunits is required for maintaining their stability in differentiated brain cells. |
| Databáze: | MEDLINE |
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