Biochemical and Functional Interplay Between Ion Channels and the Components of the Dystrophin-Associated Glycoprotein Complex.

Autor: Leyva-Leyva M; Department of Molecular Biology and Histocompatibility, 'Dr. Manuel Gea González' General Hospital, Mexico City, Mexico., Sandoval A; Faculty of Superior Studies Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla, Mexico., Felix R; Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), Mexico City, Mexico. rfelix@cell.cinvestav.mx., González-Ramírez R; Department of Molecular Biology and Histocompatibility, 'Dr. Manuel Gea González' General Hospital, Mexico City, Mexico. grricardo_gr@yahoo.com.mx.
Jazyk: angličtina
Zdroj: The Journal of membrane biology [J Membr Biol] 2018 Aug; Vol. 251 (4), pp. 535-550. Date of Electronic Publication: 2018 May 19.
DOI: 10.1007/s00232-018-0036-9
Abstrakt: Dystrophin is a cytoskeleton-linked membrane protein that binds to a larger multiprotein assembly called the dystrophin-associated glycoprotein complex (DGC). The deficiency of dystrophin or the components of the DGC results in the loss of connection between the cytoskeleton and the extracellular matrix with significant pathophysiological implications in skeletal and cardiac muscle as well as in the nervous system. Although the DGC plays an important role in maintaining membrane stability, it can also be considered as a versatile and flexible molecular complex that contribute to the cellular organization and dynamics of a variety of proteins at specific locations in the plasma membrane. This review deals with the role of the DGC in transmembrane signaling by forming supramolecular assemblies for regulating ion channel localization and activity. These interactions are relevant for cell homeostasis, and its alterations may play a significant role in the etiology and pathogenesis of various disorders affecting muscle and nerve function.
Databáze: MEDLINE
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