Diabetes-induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain.
Autor: | Ved N; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine University of Nottingham, Nottingham, NG7 2UH, UK.; Institute of Ophthalmology, 11-43 Bath St, London, EC1V 9EL, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Da Vitoria Lobo ME; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine University of Nottingham, Nottingham, NG7 2UH, UK., Bestall SM; Arthritis Research UK Pain Centre and School of Life Sciences, The Medical School QMC, University of Nottingham, Nottingham, NG7 2UH, UK., L Vidueira C; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine University of Nottingham, Nottingham, NG7 2UH, UK., Beazley-Long N; Arthritis Research UK Pain Centre and School of Life Sciences, The Medical School QMC, University of Nottingham, Nottingham, NG7 2UH, UK., Ballmer-Hofer K; Paul Scherer Institute, Villingen, 5232, Switzerland., Hirashima M; Division of Vascular Biology, Kobe University, Japan., Bates DO; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine University of Nottingham, Nottingham, NG7 2UH, UK.; Centre of Membrane and Protein and Receptors (COMPARE), University of Birmingham, Birmingham and University of Nottingham, Nottingham, UK., Donaldson LF; Institute of Ophthalmology, 11-43 Bath St, London, EC1V 9EL, UK., Hulse RP; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine University of Nottingham, Nottingham, NG7 2UH, UK.; School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. |
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Jazyk: | angličtina |
Zdroj: | The Journal of physiology [J Physiol] 2018 Aug; Vol. 596 (16), pp. 3675-3693. Date of Electronic Publication: 2018 Jul 11. |
DOI: | 10.1113/JP275067 |
Abstrakt: | Key Points: Diabetes is thought to induce neuropathic pain through activation of dorsal horn sensory neurons in the spinal cord. Here we explore the impact of hyperglycaemia on the blood supply supporting the spinal cord and chronic pain development. In streptozotocin-induced diabetic rats, neuropathic pain is accompanied by a decline in microvascular integrity in the dorsal horn. Hyperglycaemia-induced degeneration of the endothelium in the dorsal horn was associated with a loss in vascular endothelial growth factor (VEGF)-A Abstract: Abnormalities of neurovascular interactions within the CNS of diabetic patients is associated with the onset of many neurological disease states. However, to date, the link between the neurovascular network within the spinal cord and regulation of nociception has not been investigated despite neuropathic pain being common in diabetes. We hypothesised that hyperglycaemia-induced endothelial degeneration in the spinal cord, due to suppression of vascular endothelial growth factor (VEGF)-A/VEGFR2 signalling, induces diabetic neuropathic pain. Nociceptive pain behaviour was investigated in a chemically induced model of type 1 diabetes (streptozotocin induced, insulin supplemented; either vehicle or VEGF-A (© 2018 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.) |
Databáze: | MEDLINE |
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