| Autor: |
Loughlin AM; Optum Epidemiology, Boston, MA., Qiao Q; AstraZeneca, Gothenburg, Sweden., Nunes AP; Optum Epidemiology, Boston, MA., Ezzy SM; Optum Epidemiology, Boston, MA., Yochum L; Optum Epidemiology, Boston, MA., Clifford CR; Optum Epidemiology, Boston, MA., Gately RV; Optum Epidemiology, Boston, MA., Dore DD; Optum Epidemiology, Boston, MA., Seeger JD; Optum Epidemiology, Boston, MA. |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetes spectrum : a publication of the American Diabetes Association [Diabetes Spectr] 2018 May; Vol. 31 (2), pp. 129-137. |
| DOI: |
10.2337/ds16-0081 |
| Abstrakt: |
A propensity-matched cohort study compared injectable-naive patients with type 2 diabetes initiating exenatide once weekly (EQW) or basal insulin (BI), from 2012 through 2015, within a U.S. electronic health record database. A1C and weight were obtained as observed or multiply imputed values at baseline and quarterly for 1 year (Q1-Q4). Hypoglycemia and gastrointestinal symptoms were identified using diagnostic codes and clinical notes. EQW ( n = 2,008) and BI ( n = 4,016) cohorts were comparable at baseline (mean A1C and weight: EQW, 8.3% and 107.5 kg, respectively; BI, 8.5% and 107.9 kg, respectively). A1C declined in Q2: -0.69 and -0.50 percentage points for EQW and BI, respectively, with little further change in year 1. The EQW cohort lost 0.9 kg in Q1 and 1.9 kg by the end of the year; no weight change was observed in the BI cohort. Among EQW and BI cohorts, 25.9% and 14.3% achieved both glycemic control and weight loss, respectively. In the EQW and BI cohorts, the incidence of hypoglycemia per 1,000 person-years was 52.5 and 65.7, respectively. The incidence of nausea was greater among EQW relative to BI initiators (relative rate 1.18). EQW offers an advantage compared to BI in achieving glycemic control and weight loss and a lower incidence of hypoglycemia, but is associated with greater risk of gastrointestinal symptoms. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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