Assessing the efficacy of a live vaccine against avian encephalomyelitis virus.

Autor: Lin W; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, 510642, People's Republic of China.; Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangdong, 510642, Guangzhou, People's Republic of China.; South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, 510642, People's Republic of China., Lu P; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China., Li A; College of Science and Engineering, Jinan University, Guangzhou, 510632, People's Republic of China., Wu Y; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China., Li H; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China., Chen F; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, 510642, People's Republic of China.; Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangdong, 510642, Guangzhou, People's Republic of China.; South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, 510642, People's Republic of China., Ma J; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, 510642, People's Republic of China.; Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangdong, 510642, Guangzhou, People's Republic of China.; South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, 510642, People's Republic of China., Xie Q; College of Animal Science, South China Agricultural University, Guangzhou, 510642, People's Republic of China. qmx@scau.edu.cn.; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, 510642, People's Republic of China. qmx@scau.edu.cn.; Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangdong, 510642, Guangzhou, People's Republic of China. qmx@scau.edu.cn.; South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, 510642, People's Republic of China. qmx@scau.edu.cn.
Jazyk: angličtina
Zdroj: Archives of virology [Arch Virol] 2018 Sep; Vol. 163 (9), pp. 2395-2404. Date of Electronic Publication: 2018 May 16.
DOI: 10.1007/s00705-018-3862-2
Abstrakt: Avian encephalomyelitis virus (AEV) causes typical neurological symptoms in young chicks and a transient drop in egg production and hatchability in adult laying birds, resulting in huge economic losses in the poultry industry. An effective way to control and prevent this disease is vaccination of the flocks. Here, we assessed the efficacy of the live vaccine candidate strain GDt29 against avian encephalomyelitis virus. The GDt29 strain has low virulence, was confirmed safe, and showed no signs of pathogenicity. High titers of AEV-specific antibodies were detected in GDt29-vaccinated hens (S/P > 3.0) and their progeny (S/P > 2.0). Moreover, the eggs of GDt29-vaccinated hens with high levels of maternal antibodies were hatched successfully regardless of challenge with a heterologous AEV strain, and the GDt29 attenuated vaccine showed higher protective efficacy against AEV than the commercial vaccine. Furthermore, contact-exposed chicks bred with GDt29-vaccinated birds generated high titers against AE virus (S/P > 2.8). Collectively, our studies are proof of the principle that GDt29 might be an ideal vaccine candidate to prevent AEV infection, and they highlight the utility of using a live vaccine against AEV.
Databáze: MEDLINE
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