Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus.

Autor: McCoski SR; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, USA., Poole RK; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, USA., Vailes MT; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, USA., Ealy AD; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, USA. Electronic address: ealy@vt.edu.
Jazyk: angličtina
Zdroj: Reproductive biology [Reprod Biol] 2018 Jun; Vol. 18 (2), pp. 198-201.
DOI: 10.1016/j.repbio.2018.05.001
Abstrakt: The influence of exposure to overfeeding-induced maternal obesity around the time of conception on early embryogenesis was examined in the day 14 ovine conceptus. The relative abundance of FGFR2 and DNMT1 was influenced by maternal obesity status and conceptus sex, and the abundance of PPARG and PTGS2 transcripts was greater in male conceptuses regardless of the obesity status of the ewe. These observations demonstrated that short-term exposure to maternal obesity impacts early conceptus transcript patterning.
(Copyright © 2018 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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