Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy.

Autor: Fusco DN; Medicine/General Internal Medicine and Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, United States., Ganova-Raeva L; Molecular Epidemiology and Bioinformatics Team, DVH/NCHHSTP/CDC, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States., Khudyakov Y; Molecular Epidemiology and Bioinformatics Team, DVH/NCHHSTP/CDC, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States., Punkova L; Molecular Epidemiology and Bioinformatics Team, DVH/NCHHSTP/CDC, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States., Mohamed A; Cooper Medical School of Rowan University, Camden, NJ, United States., Cheon SSY; Wellesley College, Wellesley, MA, United States., Koirala P; Wellesley College, Wellesley, MA, United States., Andersson KL; Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Jourdain G; Institut de recherche pour le développement(IRD), Marseille, France.; Chiang Mai University, Chiang Mai, Thailand.; Harvard School of Public Health, Boston, MA, United States., Sureau C; Institut National de la Tranfusion Sanguine INSER U1134, Paris, France., Chung RT; Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Lauer G; Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jazyk: angličtina
Zdroj: Frontiers in medicine [Front Med (Lausanne)] 2018 Apr 30; Vol. 5, pp. 97. Date of Electronic Publication: 2018 Apr 30 (Print Publication: 2018).
DOI: 10.3389/fmed.2018.00097
Abstrakt: A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.
Databáze: MEDLINE