Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.

Autor: Shinde R; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Hezaveh K; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Halaby MJ; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Kloetgen A; Department of Pathology, New York University School of Medicine, New York, NY, USA., Chakravarthy A; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., da Silva Medina T; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Deol R; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Manion KP; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Baglaenko Y; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Eldh M; Department of Medicine, Unit for Immunology and Allergy, Karolinska Institute, Stockholm, Sweden., Lamorte S; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Wallace D; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Chodisetti SB; Department of Immunology, Pennsylvania State University School of Medicine, Hershey, PA, USA., Ravishankar B; Department of Cancer Immunology, Genentech, San Francisco, CA, USA., Liu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chaudhary K; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Munn DH; Department of Paediatrics, Medical College of Georgia, Augusta, GA, USA., Tsirigos A; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University School of Medicine, New York, NY, USA., Madaio M; Department of Medicine, Medical College of Georgia, Augusta, GA, USA., Gabrielsson S; Department of Medicine, Unit for Immunology and Allergy, Karolinska Institute, Stockholm, Sweden., Touma Z; University of Toronto Lupus Clinic, University of Toronto, Toronto, ON, Canada.; Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Wither J; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Krembil Research Institute, University Health Network, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., De Carvalho DD; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., McGaha TL; Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. tmcgaha@uhnresearch.ca.; Department of Immunology, University of Toronto, Toronto, ON, Canada. tmcgaha@uhnresearch.ca.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2018 Jun; Vol. 19 (6), pp. 571-582. Date of Electronic Publication: 2018 May 14.
DOI: 10.1038/s41590-018-0107-1
Abstrakt: The transcription factor AhR modulates immunity at multiple levels. Here we report that phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of the cytokine IL-10. Activation of AhR was dependent on interactions between apoptotic-cell DNA and the pattern-recognition receptor TLR9 that was required for the prevention of immune responses to DNA and histones in vivo. Moreover, disease progression in mouse systemic lupus erythematosus (SLE) correlated with strength of the AhR signal, and the disease course could be altered by modulation of AhR activity. Deletion of AhR in the myeloid lineage caused systemic autoimmunity in mice, and an enhanced AhR transcriptional signature correlated with disease in patients with SLE. Thus, AhR activity induced by apoptotic cell phagocytes maintains peripheral tolerance.
Databáze: MEDLINE