Characterization of sleep-pattern and neuro-immune-endocrine markers at 24 hour post-injection of a single low dose of lipopolysaccharide in male Wistar rats.

Autor: Nachón-García F; Biomedicine Department, Health Sciences Institute, Veracruzana University, Luis Castelazo-Ayala s/n. Industrial-Animas, Xalapa, Veracruz C.P. 91190 Mexico. Electronic address: fnachon@uv.mx., Hurtado-Alvarado G; Area of Neurosciences, Department of Biology of Reproduction, CBS, Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco No. 186, Colonia Vicentina, Iztapalapa, 09340 México City, Mexico., Acosta-Hernández ME; Biomedicine Department, Health Sciences Institute, Veracruzana University, Luis Castelazo-Ayala s/n. Industrial-Animas, Xalapa, Veracruz C.P. 91190 Mexico. Electronic address: mariacosta@uv.mx., Peña-Escudero C; Biomedicine Department, Health Sciences Institute, Veracruzana University, Luis Castelazo-Ayala s/n. Industrial-Animas, Xalapa, Veracruz C.P. 91190 Mexico; Master in Health Sciences Program, Veracruzana University, Luis Castelazo-Ayala s/n, Industrial-Animas, Xalapa, Veracruz C.P. 91190, Mexico., Priego-Fernández S; Biomedicine Department, Health Sciences Institute, Veracruzana University, Luis Castelazo-Ayala s/n. Industrial-Animas, Xalapa, Veracruz C.P. 91190 Mexico; Master in Health Sciences Program, Veracruzana University, Luis Castelazo-Ayala s/n, Industrial-Animas, Xalapa, Veracruz C.P. 91190, Mexico., Alvarez-Herrera S; Department of Psychoimmunology, National Institute of Psychiatry 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México City, Mexico., Becerril-Villanueva E; Department of Psychoimmunology, National Institute of Psychiatry 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México City, Mexico. Electronic address: lusenbeve@imp.edu.mx., Pérez-Sánchez G; Department of Psychoimmunology, National Institute of Psychiatry 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México City, Mexico. Electronic address: gilberto.perez.sanchez@imp.edu.mx., Pavón L; Department of Psychoimmunology, National Institute of Psychiatry 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México City, Mexico., García-García F; Biomedicine Department, Health Sciences Institute, Veracruzana University, Luis Castelazo-Ayala s/n. Industrial-Animas, Xalapa, Veracruz C.P. 91190 Mexico; Master in Health Sciences Program, Veracruzana University, Luis Castelazo-Ayala s/n, Industrial-Animas, Xalapa, Veracruz C.P. 91190, Mexico. Electronic address: fgarcia@uv.mx.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2018 Jul 15; Vol. 320, pp. 15-18. Date of Electronic Publication: 2018 Apr 17.
DOI: 10.1016/j.jneuroim.2018.04.011
Abstrakt: The long-term effect of immune system activation by a low dose of lipopolysaccharide on neuro-immune-endocrine regulation is unclear. Sleep, neurotransmitter concentrations, TNF-α, and corticosterone levels were evaluated in male Wistar rats implanted with conventional sleep recordings. In this work, we found that REM sleep was reduced in the first 4 h post-injection, without affecting the total sleep time, while adrenaline concentration was reduced in the hippocampus at 24 h post-injection of LPS. Our results demonstrated that, although the acute immune response was not evident 24 h after the injection of LPS, it was able to promote the reduction of AD in the hippocampus, which may explain in part the depressive behavior reported in rodents following LPS administration.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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