| Autor: |
Wu YY; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Gao W; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Zhang YL; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Niu M; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Cui JJ; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Xiang CX; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Sang JW; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Wen SX; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China., Wang BQ; Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University Taiyuan,030001,China. |
| Abstrakt: |
Objective: To investigate the expression of LINC00520 in laryngeal squamous cell carcinoma(LSCC),and analyze its relevance and roles in carcinogenesis and development of LSCC. Method: The expression of LINC00520 in laryngeal squamous cell carcinoma tissue and paired adjacent normal tissue was determined by real-time PCR.The relationship between the expression of LINC00520 and the clinicopathological characteristics including clinical stage,pathological type,histological grade and lymph node metastasis of LSCC was analyzed. Result: (1)The LINC00520 expression level was significantly upregulated in LSCC tissues compared to that of paired adjacent normal tissues( P <0.000 1).(2)There were no statistical differences of the LINC00520 expression level among supraglottic,glottic and subglottic LSCCs( P >0.05).The LINC00520 expression level had no significant changes in poorly differentiated LSCC compared with that of well and moderately differentiated counterparts( P >0.05).Moreover,the expression of LINC00520 had no significant difference between T1+T2 stage and T3+T4 stage LSCC tissues( P >0.05).Interestingly,the LINC00520 level in LSCC with lymph node metastasis was significantly higher than that in patients without lymph node metastasis( P <0.01). Conclusion: Upregulation of LINC00520 in LSCC may contribute to its metastasis. |
