| Autor: |
Berman JM; Merrell Dow Research Institute, Cincinnati, OH., Pelton JT, Hassman CF, Buck SH, Shea PJ, Ertl P, Heminger EF, Broersma RJ |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of peptide and protein research [Int J Pept Protein Res] 1988 Jul; Vol. 32 (1), pp. 47-55. |
| DOI: |
10.1111/j.1399-3011.1988.tb00925.x |
| Abstrakt: |
The synthesis and pharmacological activity of partial retro-inverso modified rat atrial natriuretic factor (rANF) analogs is described. The route to these compounds utilized a combination of solution and solid-phase methods. The analogs prepared all contain a reversed amide bond (psi[NHCO]) at the Ser 25 to Phe26 linkage. This bond has been suggested to play a key role in the metabolic inactivation of ANF. The analogs are of comparable potency to the endogenous peptide rANF1-28 in binding to cultured rat vascular smooth muscle cells, in relaxing serotonin contracted rabbit aortic rings, and as natriuretic/diuretic agents in anesthetized rats. None of the peptides has an extended duration of action in vivo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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