| Autor: |
Caslin HL; Department of Biology, Virginia Commonwealth University, Richmond, VA, United States., Kiwanuka KN; Department of Biology, Virginia Commonwealth University, Richmond, VA, United States., Haque TT; Department of Biology, Virginia Commonwealth University, Richmond, VA, United States., Taruselli MT; Department of Biology, Virginia Commonwealth University, Richmond, VA, United States., MacKnight HP; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, United States., Paranjape A; Department of Biology, Virginia Commonwealth University, Richmond, VA, United States., Ryan JJ; Department of Biology, Virginia Commonwealth University, Richmond, VA, United States. |
| Abstrakt: |
Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by cytokines and other microenvironmental stimuli. Playing a protective role in parasitic, bacterial, and viral infections, mast cells are also known for their role in the pathogenesis of allergy, asthma, and autoimmune diseases. Here, we review factors controlling mast cell activation, with a focus on receptor signaling and potential therapies for allergic disease. Specifically, we will discuss our work with FcεRI and FγR signaling, IL-4, IL-10, and TGF-β1 treatment, and Stat5. We conclude with potential therapeutics for allergic disease. Much of these efforts have been influenced by the work of Bill Paul. With many mechanistic targets for mast cell activation and different classes of therapeutics being studied, there is reason to be hopeful for continued clinical progress in this area. |
