Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.
| Autor: | Sutton EF; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Beyl R; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Early KS; Health, Physical Education, and Exercise Science, Columbus State University, Columbus, GA 31907, USA., Cefalu WT; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA; American Diabetes Association, Arlington, VA 22202, USA., Ravussin E; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Peterson CM; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: cpeterso@uab.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cell metabolism [Cell Metab] 2018 Jun 05; Vol. 27 (6), pp. 1212-1221.e3. Date of Electronic Publication: 2018 May 10. |
| DOI: | 10.1016/j.cmet.2018.04.010 |
| Abstrakt: | Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism. Men with prediabetes were randomized to eTRF (6-hr feeding period, with dinner before 3 p.m.) or a control schedule (12-hr feeding period) for 5 weeks and later crossed over to the other schedule. eTRF improved insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite. We demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF's effects are not solely due to weight loss. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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