Effect of obesity on biodistribution of nanoparticles.

Autor: de Jesus Felismino C; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil., Helal-Neto E; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil., Portilho FL; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil., Rocha Pinto S; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil., Sancenón F; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Caminode Vera s/n, Valencia 46022, Spain; Departamento de Química, Universidad Politécnica de Valencia, Caminode Vera s/n, Valencia 46022, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain., Martínez-Máñez R; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Caminode Vera s/n, Valencia 46022, Spain; Departamento de Química, Universidad Politécnica de Valencia, Caminode Vera s/n, Valencia 46022, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain., de Assis Ferreira A; Department of Cell Biology, Laboratory of Cellular and Molecular Pharmacology, IBRAG, Universidade do Estado do Rio de Janeiro, RJ, Brazil., da Silva SV; Department of Cell Biology, Laboratory of Cellular and Molecular Pharmacology, IBRAG, Universidade do Estado do Rio de Janeiro, RJ, Brazil., Barja-Fidalgo TC; Department of Cell Biology, Laboratory of Cellular and Molecular Pharmacology, IBRAG, Universidade do Estado do Rio de Janeiro, RJ, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil; Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Zona Oeste State University, Rio de Janeiro, Brazil. Electronic address: roliveira@ien.gov.br.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2018 Jul 10; Vol. 281, pp. 11-18. Date of Electronic Publication: 2018 May 10.
DOI: 10.1016/j.jconrel.2018.05.003
Abstrakt: Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated two nanoparticles: magnetic core mesoporous silica (MSN) (58 nm) and polycaprolactone (PCL) nanoparticle (280 nm) in obese mice. Changes in the biodistribution were observed, especially considering the mononuclear phagocyte system (MPS), and the visceral fat tissue. Nonetheless, our data corroborates the influence of size in the biodistribution in obese animals, supporting that smaller nanoparticles, may show a higher tissue deposition at spleen, due the associated splenomegaly and the complications arising from this state. Finally, our study demonstrated that, in obesity, probably due the low-grade inflammatory state associated with metabolic syndrome a difference in accumulation of nanoparticles was found, with profound impact in the tissue deposition of nanoparticles.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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