Xanthine oxidase activity exerts pro-oxidative and pro-inflammatory effects in serum of silver catfish fed with a diet contaminated with aflatoxin B 1 .

Autor: Baldissera MD; Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil., Souza CF; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil., Doleski PH; Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil., Zeppenfeld CC; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil., Descovi S; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil., Da Silva AS; Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil., Baldisserotto B; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Jazyk: angličtina
Zdroj: Journal of fish diseases [J Fish Dis] 2018 Jul; Vol. 41 (7), pp. 1153-1158. Date of Electronic Publication: 2018 May 10.
DOI: 10.1111/jfd.12812
Abstrakt: Several studies have associated the involvement of xanthine oxidase (XO) activity, a source of uric acid and reactive oxygen species (ROS), to pro-oxidative and pro-inflammatory effects during pathological conditions. Considering this, the aim of this study was to evaluate whether upregulation on seric XO activity may be a pathway involved in the oxidative stress in fish exposed to a diet contaminated with aflatoxin B 1 (AFB 1 ), as well as whether it may be considered a pathway involved in ROS and NOx production. Xanthine oxidase activity, as well as the uric acid, ROS and NOx levels increased in serum of fish fed with a AFB 1 -contaminated diet on days 14 and 21 post-feeding compared to fish fed with a basal diet. Based on these evidences, upregulation of seric XO activity induces pro-oxidant and pro-inflammatory profiles in serum of fish fed with a AFB 1 -contaminated diet due to excessive formation on uric acid. Also, the excessive uric acid induces the release of pro-oxidant and pro-inflammatory mediators, as ROS and NOx, also contributing to oxidative and inflammatory profiles. In summary, the upregulation on seric XO activity may be considered a pathway involved in the oxidative stress of fish exposed to a diet contaminated with AFB 1 .
(© 2018 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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