[Relationship between the FSHR Thr307Ala-Asn680Ser gene polymorphism and male infertility: A meta-analysis].

Autor:	Luo J; Central Laboratory, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China.; Department of Clinical Laboratory, Jiangsu Provincial Agency Hospital, Nanjing, Jiangsu 210002, China., Wang L; Department of Clinical Laboratory, The Second Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210002, China., Shi HC; Department of Clinical Laboratory, Jiangsu Provincial Agency Hospital, Nanjing, Jiangsu 210002, China., Zeng QQ; Central Laboratory, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China., Wu QY; PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China., Li WW; PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Jazyk:	čínština
Zdroj:	Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2017 Dec; Vol. 23 (12), pp. 1121-1126.
Abstrakt:	Objective: To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility. Methods: We searched Pubmed, EMBASE, Web of Science, CNKI, and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time. According to the inclusion criteria, we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software. Results: A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies. The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model, hybrid comparison model and dominant comparison model), with the pooled odds ratios (OR) of 1.26 (95% CI: 1.03－1.54, P = 0.023), 1.18 (95% CI: 1.03－1.36, P = 0.018), and 1.20 (95% CI: 1.05－1.37, P = 0.006), respectively. And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models, with the pooled ORs of 1.24, (95% CI: 1.05－1.45, P = 0.009) and 1.20 (95% CI: 1.04－1.39, P = 0.013), respectively. Layered meta-analysis showed that in the homozygous comparison model, the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population, with the OR of 1.37 (95% CI: 1.03－1.82, P = 0.003) and 1.21 (95% CI: 1.00－1.47, P = 0.048), respectively. Conclusions: In the homozygous model (GG vs AA), the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility.
Databáze:	MEDLINE
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