Recent Advances in Understanding the Pathogenesis of Cardiovascular Diseases and Development of Treatment Modalities.

Autor:	Mittal R; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Jhaveri VM; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Kay SS; College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida FL, United States., Greer A; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Sutherland KJ; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., McMurry HS; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Lin N; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Mittal J; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Malhotra AK; Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida FL, United States., Patel AP; College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida FL, United States.
Jazyk:	angličtina
Zdroj:	Cardiovascular & hematological disorders drug targets [Cardiovasc Hematol Disord Drug Targets] 2019; Vol. 19 (1), pp. 19-32.
DOI:	10.2174/1871529X18666180508111353
Abstrakt:	Cardiovascular Diseases (CVDs) are a leading cause of morbidity and mortality worldwide. The underlying pathology for cardiovascular disease is largely atherosclerotic in nature and the steps include fatty streak formation, plaque progression and plaque rupture. While there is optimal drug therapy available for patients with CVD, there are also underlying drug delivery obstacles that must be addressed. Challenges in drug delivery warrant further studies for the development of novel and more efficacious medical therapies. An extensive understanding of the molecular mechanisms of disease in combination with current challenges in drug delivery serves as a platform for the development of novel drug therapeutic targets for CVD. The objective of this article is to review the pathogenesis of atherosclerosis, first-line medical treatment for CVD, and key obstacles in an efficient drug delivery. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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