Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders.

Autor: Ratto-Kim S; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.; 2 Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, Maryland., Schuetz A; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.; 2 Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, Maryland.; 3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand ., Sithinamsuwan P; 4 Division of Neurology, Department of Medicine, Phramongkutklao Hospital , Bangkok, Thailand ., Barber J; 5 Clinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland., Hutchings N; 6 Columbia University College of Physicians and Surgeons , New York, New York., Lerdlum S; 7 Department of Radiology, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand ., Fletcher JLK; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Phuang-Ngern Y; 3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand ., Chuenarom W; 3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand ., Tipsuk S; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Pothisri M; 7 Department of Radiology, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand ., Jadwattanakul T; 9 Department of Neurology, Washington University in St. Louis , St. Louis, Missouri., Jirajariyavej S; 10 HIV Clinic, Taksin Hospital , Bangkok, Thailand ., Sajjaweerawan C; 3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand ., Akapirat S; 3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand ., Chalermchai T; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Suttichom D; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Kaewboon B; 3 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences-United States Component , Bangkok, Thailand ., Prueksakaew P; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Karnsomlap P; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Clifford D; 11 Department of Psychology, University of Missouri , St. Louis, Missouri., Paul RH; 11 Department of Psychology, University of Missouri , St. Louis, Missouri., de Souza MS; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Kim JH; 12 International Vaccine Institute , Seoul, Korea., Ananworanich J; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.; 2 Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, Maryland.; 8 SEARCH, Thai Red Cross AIDS Research Center , Bangkok, Thailand ., Valcour V; 13 Memory and Aging Center, Department of Neurology, University of California , San Francisco, California.
Jazyk: angličtina
Zdroj: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2018 Aug; Vol. 34 (8), pp. 685-689. Date of Electronic Publication: 2018 Jun 12.
DOI: 10.1089/AID.2017.0237
Abstrakt: HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8 + T cell activation (HLA-DR + /CD38 + ) and HIV-specific CD8 + T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8 + T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b + ) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8 + T cells in the mechanism of HAND development.
Databáze: MEDLINE