Aging of monolithic zirconia dental prostheses: Protocol for a 5-year prospective clinical study using e x vivo analyses.

Autor:	Koenig V; Dental Biomaterials Research Unit (d-BRU) and Department of Fixed Prosthodontics, Institute of Dentistry, University of Liège (ULg) and University of Liège Hospital (CHU), 45 Quai G. Kurth, Liège, 4020, Belgium., Wulfman CP; Unité de Recherches en Biomatériaux Innovants et Interfaces (URB2i) - EA442, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris-Cité, Montrouge, 92120, France.; Service d'odontologie, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris (URB2i), France., Derbanne MA; Unité de Recherches en Biomatériaux Innovants et Interfaces (URB2i) - EA442, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris-Cité, Montrouge, 92120, France., Dupont NM; Dental Biomaterials Research Unit (d-BRU) and Department of Fixed Prosthodontics, Institute of Dentistry, University of Liège (ULg) and University of Liège Hospital (CHU), 45 Quai G. Kurth, Liège, 4020, Belgium., Le Goff SO; Unité de Recherches en Biomatériaux Innovants et Interfaces (URB2i) - EA442, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris-Cité, Montrouge, 92120, France., Tang ML; Unité de Recherches en Biomatériaux Innovants et Interfaces (URB2i) - EA442, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris-Cité, Montrouge, 92120, France., Seidel L; Biostatistics Department, University Hospital of Liège, Belgium., Dewael TY; Dental Biomaterials Research Unit (d-BRU) and Department of Fixed Prosthodontics, Institute of Dentistry, University of Liège (ULg) and University of Liège Hospital (CHU), 45 Quai G. Kurth, Liège, 4020, Belgium., Vanheusden AJ; Dental Biomaterials Research Unit (d-BRU) and Department of Fixed Prosthodontics, Institute of Dentistry, University of Liège (ULg) and University of Liège Hospital (CHU), 45 Quai G. Kurth, Liège, 4020, Belgium., Mainjot AK; Dental Biomaterials Research Unit (d-BRU) and Department of Fixed Prosthodontics, Institute of Dentistry, University of Liège (ULg) and University of Liège Hospital (CHU), 45 Quai G. Kurth, Liège, 4020, Belgium.; Unité de Recherches en Biomatériaux Innovants et Interfaces (URB2i) - EA442, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris-Cité, Montrouge, 92120, France.
Jazyk:	angličtina
Zdroj:	Contemporary clinical trials communications [Contemp Clin Trials Commun] 2016 Jun 17; Vol. 4, pp. 25-32. Date of Electronic Publication: 2016 Jun 17 (Print Publication: 2016).
DOI:	10.1016/j.conctc.2016.06.001
Abstrakt:	Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a well-known problem with zirconia hip prostheses. This phenomenon could be accentuated by masticatory mechanical stress. Until now zirconia LTD process has only been studied in vitro . This work introduces an original protocol to evaluate LTD process of monolithic zirconia prostheses in the oral environment and to study their general clinical behavior, notably in terms of wear. Methods/design: 101 posterior monolithic zirconia tooth elements (molars and premolars) are included in a 5-year prospective clinical trial. On each element, several areas between 1 and 2 mm 2 (6 on molars, 4 on premolars) are determined on restoration surface: areas submitted or non-submitted to mastication mechanical stress, glazed or non-glazed. Before prosthesis placement, ex vivo analyses regarding LTD and wear are performed using Raman spectroscopy, SEM imagery and 3D laser profilometry. After placement, restorations are clinically evaluated following criteria of the World Dental Federation (FDI), complemented by the analysis of fracture clinical risk factors. Two independent examiners perform the evaluations. Clinical evaluation and ex vivo analyses are carried out after 6 months and then each year for up to 5 years. Discussion: For clinicians and patients, the results of this trial will justify the use of monolithic zirconia restorations in dental practice. For researchers, the originality of a clinical study including ex vivo analyses of material aging will provide important data regarding zirconia properties.Trial registration: ClinicalTrials.gov Identifier: NCT02150226.
Databáze:	MEDLINE
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