Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States.

Autor: Nersesian PV; Johns Hopkins School of Nursing, 525 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: pnersesian@jhu.edu., Han HR; Johns Hopkins School of Nursing, 525 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: hhan2@jhu.edu., Yenokyan G; Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: gyenoky1@jhu.edu., Blumenthal RS; Johns Hopkins School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA. Electronic address: rblument@jhmi.edu., Nolan MT; Johns Hopkins School of Nursing, 525 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: mnolan3@jhu.edu., Hladek MD; Johns Hopkins School of Nursing, 525 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: mhladek1@jhu.edu., Szanton SL; Johns Hopkins School of Nursing, 525 N. Wolfe St., Baltimore, MD 21205, USA; Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: sszanto1@jhu.edu.
Jazyk: angličtina
Zdroj: Social science & medicine (1982) [Soc Sci Med] 2018 Jul; Vol. 209, pp. 174-181. Date of Electronic Publication: 2018 Apr 30.
DOI: 10.1016/j.socscimed.2018.04.007
Abstrakt: Objective: Middle-aged adults who are lonely have an elevated likelihood of death. Systemic inflammation may contribute to these increased odds. Using population-level data, this study tested if systemic inflammation is associated with loneliness in a broad age range of middle-aged adults in the United States.
Methods: This study used data from the Midlife in the US (MIDUS) survey Biomarker Project, which collected data on psychological, social, and physiological measures from a sample of middle-aged adults. This sample included the 927 participants who were 35-64 years at Biomarker Project data collection. MIDUS collected baseline data from 1995-1996 and a follow-up survey was conducted from 2004-2006. The baseline Milwaukee sample of African Americans was collected in 2005-2006 and the biomarker database was collected in 2004-2009. Biomarkers were obtained from a fasting blood sample. Self-reported loneliness was categorized as feeling lonely or not feeling lonely. Hierarchical regressions examined the association between biomarkers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein) and feeling lonely, adjusted for covariates.
Results: Twenty-nine percent of the sample reported feeling lonely most or some of the time. There was a positive significant relationship between loneliness and the three systemic inflammation biomarkers after controlling for covariates: interleukin-6 (n = 873) (b [se] = 0.07 [0.03], p = .014); fibrinogen (n = 867) (b [se] = 18.24 [7.12], p = .011); and C-reactive protein (n = 867) (b [se] = 0.08 [0.04], p = .035).
Conclusions: Feeling lonely is associated with systemic inflammation in middle-aged community-dwelling US adults.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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