Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength.

Autor:	Cha HN; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Park S; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Dan Y; Weinberg College of Art and Sciences, Northwestern University, Chicago, Illinois., Kim JR; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea.; Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea., Park SY; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2019 Jan 16; Vol. 74 (2), pp. 147-154.
DOI:	10.1093/gerona/gly113
Abstrakt:	This study examined the role of peroxiredoxin2 (Prx2) in aging-induced insulin resistance and reduction in skeletal muscle function in young (2-month-old) and old (24-month-old) Prx2 knockout (KO) and wild-type mice. Plasma insulin levels increased with aging in Prx2 KO mice but not in wild-type mice. Insulin sensitivity in the whole-body and skeletal muscle as assessed with the hyperinsulinemic-euglycemic clamp was lower in Prx2 KO mice than in wild-type mice in the old group but was not significantly different between the two genotypes in the young group. Insulin-induced activation of intracellular signaling molecules was also suppressed in old Prx2 KO mice compared to their wild-type littermates. Oxidative stress, inflammation, and p53 expression levels in skeletal muscle were higher in Prx2 KO mice than in wild-type mice in the old group but were not different between the two genotypes in the young group. p53 expression was negatively correlated with skeletal muscle insulin sensitivity in old mice. Skeletal muscle mass was similar between the two genotypes but grip strength was reduced in old Prx2 KO mice compared to old wild-type mice. These results suggest that Prx2 plays a protective role in aging-induced insulin resistance and declines in muscle strength by suppressing oxidative stress.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu