Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer.

Autor: Semkina AS; Pirogov Russian National Research Medical University, Moscow, Russian Federation; The National University of Science and Technology MISiS, Moscow, Russian Federation., Abakumov MA; Pirogov Russian National Research Medical University, Moscow, Russian Federation; The National University of Science and Technology MISiS, Moscow, Russian Federation. Electronic address: abakumov1988@gmail.com., Skorikov AS; Lomonosov Moscow State University, Moscow, Russian Federation., Abakumova TO; Skolkovo Institute of Science and Technology, Moscow, Russian Federation., Melnikov PA; Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation., Grinenko NF; Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation., Cherepanov SA; Pirogov Russian National Research Medical University, Moscow, Russian Federation; Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation., Vishnevskiy DA; Pirogov Russian National Research Medical University, Moscow, Russian Federation., Naumenko VA; The National University of Science and Technology MISiS, Moscow, Russian Federation., Ionova KP; Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation., Majouga AG; The National University of Science and Technology MISiS, Moscow, Russian Federation; Lomonosov Moscow State University, Moscow, Russian Federation; Dmitry Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation., Chekhonin VP; Pirogov Russian National Research Medical University, Moscow, Russian Federation; Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation.
Jazyk: angličtina
Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2018 Jul; Vol. 14 (5), pp. 1733-1742. Date of Electronic Publication: 2018 May 03.
DOI: 10.1016/j.nano.2018.04.019
Abstrakt: In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRI) of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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