Kolaviron protects the brain in cuprizone-induced model of experimental multiple sclerosis via enhancement of intrinsic antioxidant mechanisms: Possible therapeutic applications?

Autor: Omotoso GO; Division of Neurobiology, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria. Electronic address: gabrielolaiya@yahoo.com., Ukwubile II; Division of Neurobiology, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria., Arietarhire L; Division of Neurobiology, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria., Sulaimon F; Division of Neurobiology, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria., Gbadamosi IT; Division of Neurobiology, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria.
Jazyk: angličtina
Zdroj: Pathophysiology : the official journal of the International Society for Pathophysiology [Pathophysiology] 2018 Dec; Vol. 25 (4), pp. 299-306. Date of Electronic Publication: 2018 Apr 27.
DOI: 10.1016/j.pathophys.2018.04.004
Abstrakt: Multiple sclerosis is a demyelinating condition of the central nervous system which commonly affects young adults. Kolaviron, a biflavonoid isolate of Garcinia kola, has been used in experimental studies which explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed at unraveling the possible ameliorative effect of kolaviron on cuprizone-induced demyelination in the prefrontal cortices of Wistar rats. A total of 28 adult male Wistar rats were divided into four groups A-D. Group A received corn oil (Control), group B received 0.2% Cuprizone, group C received kolaviron (200 mg/kg bw), while group D rats were treated concomitantly with both kolaviron and cuprizone. All groups were treated for 42 days, after which behavioral, histological, immunohistochemical and biochemical analyses were carried out on the prefrontal cortices. Cuprizone significantly down-regulated the level of superoxide dismutase, exacerbated lipid peroxidation and, reduced spatial memory. Cuprizone also induced peripheral and central chromatolysis alongside with atrophied astrocytes in the prefrontal cortex. These alterations were significantly prevented in kolaviron-treated rats, as kolaviron sustained the integrity of neuronal and non-neuronal cells. The activity of kolaviron observed in this study was due to its intrinsic antioxidant properties, which enabled it to combat oxidative damage induced by cuprizone, thereby making kolaviron a potential tool in neurodegeneration therapy of demyelination origin.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: