Improved anticancer properties of stem cells derived exosomes by prolonged release from PCL nanofibrous structure.

Autor: Rezaie Z; Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran., Ardeshirylajimi A; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: ardeshirylajimi@sbmu.ac.ir., Ashkezari MD; Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran. Electronic address: mdashkezary@yahoo.com.
Jazyk: angličtina
Zdroj: Gene [Gene] 2018 Jul 30; Vol. 665, pp. 105-110. Date of Electronic Publication: 2018 May 02.
DOI: 10.1016/j.gene.2018.05.003
Abstrakt: Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells derived microvesicles (MVs) was incorporated into Polycaprolactone nanofibers and then the apoptotic behavior of MCF-7 breast cancer cells was investigated while cultured on MVs-Polycaprolactone by using SEM, MTT and apoptotic gene expression. Results demonstrated that MVs-Polycaprolactone group was shown a great apoptosis induction potential into MCF-7 cells and it can be concluded that MVs-Polycaprolactone has a great promising potential to introduce as an in-situ tumor inhibitor construct rather than chemo-drugs.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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