The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies.

Autor: Beekhuijzen M; Charles River, 's-Hertogenbosch, The Netherlands. Electronic address: manon.beekhuijzen@crl.com., Schneider S; BASF SE, Ludwigshafen am Rhein, Germany., Barraclough N; Covance Laboratories Ltd., Harrogate, United Kingdom., Hallmark N; Bayer S.A.S. Crop Science Division, Sophia Antipolis Cedex, France., Hoberman A; Charles River, Horsham, PA, USA., Lordi S; Charles River, Horsham, PA, USA., Moxon M; Regulatory Science Associates, Inverkip, United Kingdom., Perks D; Covance Laboratories Ltd., Harrogate, United Kingdom., Piersma AH; National Institute for Public Health and the Environment (RIVM), Bilthoven, and Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Makris SL; US Environmental Protection Agency, National Center for Environmental Assessment, WA, DC, USA.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2018 Sep; Vol. 80, pp. 126-130. Date of Electronic Publication: 2018 May 02.
DOI: 10.1016/j.reprotox.2018.04.017
Abstrakt: In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: