Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury.
Autor: | Sergeeva EG; Department of Emergency Medicine, Emory University, 1365B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA. Electronic address: elenagen.sergeeva@gmail.com., Espinosa-Garcia C; Department of Emergency Medicine, Emory University, 1365B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA., Atif F; Department of Emergency Medicine, Emory University, 1365B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA., Pardue MT; Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA; Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive, Atlanta, GA 30332, USA., Stein DG; Department of Emergency Medicine, Emory University, 1365B Clifton Road NE, Suite 5100, Atlanta, GA 30322, USA. Electronic address: Dstei04@emory.edu. |
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Jazyk: | angličtina |
Zdroj: | Experimental neurology [Exp Neurol] 2018 Aug; Vol. 306, pp. 138-148. Date of Electronic Publication: 2018 May 02. |
DOI: | 10.1016/j.expneurol.2018.05.005 |
Abstrakt: | In adult mice with unilateral optic nerve crush injury (ONC), we studied visual response plasticity in the visual cortex following stimulation with sinusoidal grating. We examined visually evoked potentials (VEP) in the primary visual cortex ipsilateral and contralateral to the crushed nerve. We found that unilateral ONC induces enhancement of visual response on the side ipsilateral to the injury that is evoked by visual stimulation to the intact eye. This enhancement was associated with supranormal spatial frequency thresholds in the intact eye when tested using optomotor response. To probe whether injury-induced disinhibition caused the potentiation, we treated animals with the neurosteroid allopregnanolone, a potent agonist of the GABA (Copyright © 2018 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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