| Autor: |
Gualtieri AF; Department of Chemical and Geological Sciences, The University of Modena and Reggio Emilia, Modena, Italy. alessandro.gualtieri@unimore.it., Pollastri S; Department of Chemical and Geological Sciences, The University of Modena and Reggio Emilia, Modena, Italy., Bursi Gandolfi N; Department of Chemical and Geological Sciences, The University of Modena and Reggio Emilia, Modena, Italy., Gualtieri ML; Department of Engineering 'Enzo Ferrari', The University of Modena and Reggio Emilia, Modena, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Scientific reports [Sci Rep] 2018 May 04; Vol. 8 (1), pp. 7071. Date of Electronic Publication: 2018 May 04. |
| DOI: |
10.1038/s41598-018-25531-4 |
| Abstrakt: |
The study of the mechanisms by which mineral fibres promote adverse effects in both animals and humans is a hot topic of multidisciplinary research with many aspects that still need to be elucidated. Besides length and diameter, a key parameter that determines the toxicity/pathogenicity of a fibre is biopersistence, one component of which is biodurability. In this paper, biodurability of mineral fibres of social and economic importance (chrysotile, amphibole asbestos and fibrous erionite) has been determined for the first time in a systematic comparative way from in vitro acellular dissolution experiments. Dissolution was possible using the Gamble solution as simulated lung fluid (pH = 4 and at body temperature) so to reproduce the macrophage phagolysosome environment. The investigated mineral fibres display very different dissolution rates. For a 0.25 μm thick fibre, the calculated dissolution time of chrysotile is in the range 94-177 days, very short if compared to that of amphibole fibres (49-245 years), and fibrous erionite (181 years). Diffraction and SEM data on the dissolution products evidence that chrysotile rapidly undergoes amorphization with the formation of a nanophasic silica-rich fibrous metastable pseudomorph as first dissolution step whereas amphibole asbestos and fibrous erionite show minor signs of dissolution even after 9-12 months. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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