| Autor: |
Boudjada A; Laboratory of Natural Product from Plants and Organic Synthesis, Department of Chemistry, Faculty of Sciences, University of Mentouri-Constantine , Constantine , Algeria., Touil A; Laboratory of Natural Product from Plants and Organic Synthesis, Department of Chemistry, Faculty of Sciences, University of Mentouri-Constantine , Constantine , Algeria., Bensouici C; Centre de Recherche en Biotechnologie , Constantine , Algeria., Bendif H; Department of Natural and Life Sciences, Faculty of Sciences, University of Mohamed Boudiaf , M'sila , Algeria ., Rhouati S; Laboratory of Natural Product from Plants and Organic Synthesis, Department of Chemistry, Faculty of Sciences, University of Mentouri-Constantine , Constantine , Algeria. |
| Abstrakt: |
Five phenanthrene and two dihydrophenanthrene derivatives were isolated from the diethyl ether extract of fresh rhizomes of Dioscorea communis (L.), among them a phenanthrentriol 1 reported for the first time from Dioscoreaceae family and two dihydrophenanthrene derivatives 6 and 7 reported also for the first time from Dioscorea species. The structures of isolated compounds were elucidated using UV, IR, 1D-, 2D-NMR, and MS techniques. The anticholinesterase activity of extracts and four compounds was evaluated for the first time against acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes using Ellman method. Moreover, the antioxidant activity of extracts and three compounds has been investigated using DPPH radical scavenging, ABTS cation radical decolorization, CUPRAC, reducing power and β-carotene bleaching assays. |
