Melioidosis in Thailand: Present and Future.

Autor:	Hinjoy S; Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand., Hantrakun V; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Kongyu S; Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand., Kaewrakmuk J; Faculty of Science, Prince of Songkla University, Songkla 90110, Thailand., Wangrangsimakul T; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Jitsuronk S; Faculty of Medicine, Prince of Songkla University, Songkla 90110, Thailand., Saengchun W; Department of Clinical Pathology, Chiang Rai Prachanukroh Hospital, Chiang Rai 57000, Thailand., Bhengsri S; Division of Global Health Protection, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand., Akarachotpong T; Division of Global Health Protection, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand., Thamthitiwat S; Division of Global Health Protection, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand., Sangwichian O; Division of Global Health Protection, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand., Anunnatsiri S; Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Sermswan RW; Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Lertmemongkolchai G; The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand., Tharinjaroen CS; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand., Preechasuth K; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand., Udpaun R; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand., Chuensombut P; Department of Clinical Pathology, Chiangkham Hospital, Phayao 56110, Thailand., Waranyasirikul N; Department of Clinical Pathology, Somdejphrajaotaksin Maharaj Hospital, Tak 63000, Thailand., Anudit C; Department of Clinical Pathology, Uthai Thani Hospital, Uthai Thani 61000, Thailand., Narenpitak S; Department of Internal Medicine, Udon Thani Hospital, Udon Thani 41000, Thailand., Jutrakul Y; Department of Clinical Pathology, Udon Thani Hospital, Udon Thani 41000, Thailand., Teparrukkul P; Department of Internal Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani 34000, Thailand., Teerawattanasook N; Department of Clinical Pathology, Sunpasitthiprasong Hospital, Ubon Ratchathani 34000, Thailand., Thanvisej K; Department of Internal Medicine, Nakhon Panom Hospital, Nakhon Panom 48000, Thailand., Suphan A; Ubon Ratchathani Provincial Public Health Office, Ubon Ratchathani 34000, Thailand., Sukbut P; Mukdahan Provincial Public Health Office, Mukdahan 49000, Thailand., Ploddi K; The Office of Disease Prevention and Control 8, Udon Thani 41000, Thailand., Sirichotirat P; The Office of Disease Prevention and Control 10, Ubon Ratchathani 34000, Thailand., Chiewchanyon B; The Office of Disease Prevention and Control 12, Songkla 90000, Thailand., Rukseree K; Mahidol University Amnatcharoen Campus, Amnatcharoen 37000, Thailand., Hongsuwan M; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Wongsuwan G; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Sunthornsut P; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Wuthiekanun V; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Sachaphimukh S; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Wannapinij P; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Chierakul W; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Chewapreecha C; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Thaipadungpanit J; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Chantratita N; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.; Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Korbsrisate S; Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Taunyok A; Department of Infectious Diseases & Immunology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32611, USA., Dunachie S; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Palittapongarnpim P; National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand.; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Sirisinha S; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Kitphati R; Institute for Urban Disease Control and Prevention, Department of Disease Control, Ministry of Public Health, Bangkok 10220, Thailand., Iamsirithaworn S; Bureau of General Communicable Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand., Chaowagul W; Department of Internal Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani 34000, Thailand., Chetchotisak P; Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Whistler T; Division of Global Health Protection, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand., Wongratanacheewin S; Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand., Limmathurotsakul D; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Jazyk:	angličtina
Zdroj:	Tropical medicine and infectious disease [Trop Med Infect Dis] 2018; Vol. 3 (2), pp. 38. Date of Electronic Publication: 2018 Apr 08.
DOI:	10.3390/tropicalmed3020038
Abstrakt:	A recent modelling study estimated that there are 2800 deaths due to melioidosis in Thailand yearly. The Thailand Melioidosis Network (formed in 2012) has been working closely with the Ministry of Public Health (MoPH) to investigate and reduce the burden of this disease. Based on updated data, the incidence of melioidosis is still high in Northeast Thailand. More than 2000 culture-confirmed cases of melioidosis are diagnosed in general hospitals with microbiology laboratories in this region each year. The mortality rate is around 35%. Melioidosis is endemic throughout Thailand, but it is still not uncommon that microbiological facilities misidentify Burkholderia pseudomallei as a contaminant or another organism. Disease awareness is low, and people in rural areas neither wear boots nor boil water before drinking to protect themselves from acquiring B. pseudomallei . Previously, about 10 melioidosis deaths were formally reported to the National Notifiable Disease Surveillance System (Report 506) each year, thus limiting priority setting by the MoPH. In 2015, the formally reported number of melioidosis deaths rose to 112, solely because Sunpasithiprasong Hospital, Ubon Ratchathani province, reported its own data ( n = 107). Melioidosis is truly an important cause of death in Thailand, and currently reported cases (Report 506) and cases diagnosed at research centers reflect the tip of the iceberg. Laboratory training and communication between clinicians and laboratory personnel are required to improve diagnosis and treatment of melioidosis countrywide. Implementation of rapid diagnostic tests, such as a lateral flow antigen detection assay, with high accuracy even in melioidosis-endemic countries such as Thailand, is critically needed. Reporting of all culture-confirmed melioidosis cases from every hospital with a microbiology laboratory, together with final outcome data, is mandated under the Communicable Diseases Act B.E.2558. By enforcing this legislation, the MoPH could raise the priority of this disease, and should consider implementing a campaign to raise awareness and melioidosis prevention countrywide. Competing Interests: Conflicts of Interest: The authors declare no conflict of interest.
Databáze:	MEDLINE
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