| Autor: |
Di Bonaventura I; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch., Baeriswyl S, Capecchi A, Gan BH, Jin X, Siriwardena TN, He R, Köhler T, Pompilio A, Di Bonaventura G, van Delden C, Javor S, Reymond JL |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2018 May 15; Vol. 54 (40), pp. 5130-5133. |
| DOI: |
10.1039/c8cc02412j |
| Abstrakt: |
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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