Gallbladder carcinoma: An analysis of the national cancer data base to examine hispanic influence.

Autor: Liu C; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Berger NG; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Rein L; Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin., Tarima S; Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin., Clarke C; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Mogal H; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Christians KK; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Tsai S; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Gamblin TC; Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jazyk: angličtina
Zdroj: Journal of surgical oncology [J Surg Oncol] 2018 Jun; Vol. 117 (8), pp. 1664-1671. Date of Electronic Publication: 2018 May 01.
DOI: 10.1002/jso.25050
Abstrakt: Background: Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non-Hispanic populations.
Methods: Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined.
Results: The study identified 12 952 patients. Median age was 71 years and 68.8% were female. The study characterized 69.8% White, 13.9% Black, 11.0% Hispanic, and 5.4% other patients. A 5-year OS curves differed, with survival highest in Hispanic patients (27% vs 23% Other, 18% White, and 17% Black, P < 0.001). Hispanics presented at younger ages (67 vs 72 years, P < 0.001), were more likely to be uninsured (17.3% vs 3.9% P < 0.001), had lower income (P < 0.001), and education levels (P < 0.001) compared to Whites. Following multivariable modeling, treatment at an academic facility (HR 0.90, 95%CI 0.84-0.97) and year of diagnosis (HR 0.90, 95%CI 0.88-0.92) related to survival. Hispanic ethnicity did not show significance (P = 0.207).
Discussion: Hispanic ethnicity exhibits the highest OS for GBC, but after adjusting for covariates, this influence is not significant.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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