Novel diffuse optics system for continuous tissue viability monitoring - extended recovery in vivo testing in a porcine flap model.

Autor: Lee SY; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109., Pakela JM; Applied Physics Program, University of Michigan, Ann Arbor, MI 48109., Hedrick TL; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109., Vishwanath K; Department of Physics, Miami University, Oxford, OH 45056., Helton MC; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109., Chung Y; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109., Kolodziejski NJ; Radiation Monitoring Devices, Inc., Watertown, MA 02472., Stapels CJ; Radiation Monitoring Devices, Inc., Watertown, MA 02472., McAdams DR; Radiation Monitoring Devices, Inc., Watertown, MA 02472., Fernandez DE; Radiation Monitoring Devices, Inc., Watertown, MA 02472., Christian JF; Radiation Monitoring Devices, Inc., Watertown, MA 02472., O'Reilly J; Radiation Monitoring Devices, Inc., Watertown, MA 02472.; Northeastern University, Boston, MA., Farkas D; Radiation Monitoring Devices, Inc., Watertown, MA 02472.; Northeastern University, Boston, MA., Ward BB; Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Feinberg SE; Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109., Mycek MA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.; Applied Physics Program, University of Michigan, Ann Arbor, MI 48109.
Jazyk: angličtina
Zdroj: Proceedings of SPIE--the International Society for Optical Engineering [Proc SPIE Int Soc Opt Eng] 2017 Jan-Feb; Vol. 10054. Date of Electronic Publication: 2017 Feb 14.
DOI: 10.1117/12.2252295
Abstrakt: In reconstructive surgery, tissue perfusion/vessel patency is critical to the success of microvascular free tissue flaps. Early detection of flap failure secondary to compromise of vascular perfusion would significantly increase the chances of flap salvage. We have developed a compact, clinically-compatible monitoring system to enable automated, minimally-invasive, continuous, and quantitative assessment of flap viability/perfusion. We tested the system's continuous monitoring capability during extended non-recovery surgery using an in vivo porcine free flap model. Initial results indicated that the system could assess flap viability/perfusion in a quantitative and continuous manner. With proven performance, the compact form constructed with cost-effective components would make this system suitable for clinical translation.
Databáze: MEDLINE
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