Does blood group affect survival following pancreatoduodenectomy for periampullary malignancy?

Autor:	Khalil K; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Bansal S; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Ayaani S; University Hospitals Coventry and Warwickshire, UK., Hodson J; Medical Statistician, University Hospitals Birmingham, UK., Lam FT; University Hospitals Coventry and Warwickshire, UK., Khan S; University Hospitals Coventry and Warwickshire, UK., Ahmad J; University Hospitals Coventry and Warwickshire, UK., Isaac J; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Muiesan P; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Mirza D; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Dasari B; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Marudanayagam R; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Sutcliffe RP; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK., Marangoni G; University Hospitals Coventry and Warwickshire, UK., Roberts KJ; The HPB Unit. University Hospitals Birmingham NHS Foundation Trust, UK. Electronic address: Keith.roberts@uhb.nhs.uk.
Jazyk:	angličtina
Zdroj:	HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2018 Sep; Vol. 20 (9), pp. 848-853. Date of Electronic Publication: 2018 Apr 26.
DOI:	10.1016/j.hpb.2018.03.009
Abstrakt:	Background: Blood group is reported to have an effect upon survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma. The effect of blood group is not known, however, among patients with other periampullary cancers. This study sought to review this. Methods: Data were collected for a range of factors and survival outcomes from patients treated at two centres. Those with blood groups B and AB were excluded, due to small numbers. Patient survival was compared between patients with blood groups O and A using multivariable analysis which accounted for confounding factors. Results: Among 431 patients, 235 (54.5%) and 196 (45.5%) were of blood groups A and O respectively. Baseline comparisons found a significant difference in the distribution of tumour types (p = 0.011), with blood group O patients having more ampullary carcinomas (33.2% vs 23.4%) and less pancreatic ductal adenocarcinomas (45.4 vs 61.3%) than group A. On multivariable analysis, after accounting for confounding factors including pathologic variables, survival was found to be significantly shorter in those with blood group A than group O (p = 0.047, HR 1.30 [95%CI: 1.00-1.69]). Conclusions: There is a difference in the distribution of blood groups across the different types of periampullary cancers. Survival is shorter among blood group A patients. (Copyright © 2018 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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