Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models.

Autor: De Sales IRP; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: igor_caraubas@hotmail.com., Formiga RO; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: rodrigo.formiga@hotmail.com., Machado FDF; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: flaviadanniele@hotmail.com., Nascimento RF; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: raphaela-f-21@hotmail.com., Pessoa MMB; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: mmarleybp@gmail.com., Barros MEFX; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: monique_emanuela100@hotmail.com., Vieira GC; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: gicianecvieira@ccs.ufpb.br., Gadelha FAAF; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: allyssonassis@hotmail.com., Marinho AF; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: alexsandromarinho@ltf.ufpb.br., Barbosa Filho JM; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: jbarbosa@ltf.ufpb.br., Júnior RFA; Department of Biophysics and Pharmacology and Department of Morphology, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. Electronic address: aurigena@ufrnet.br., Antunes AA; Department of Biophysics and Pharmacology and Department of Morphology, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil. Electronic address: araujojr@cb.ufrn.br., Batista LM; Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil. Electronic address: leoniab@uol.com.br.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2018 Aug 10; Vol. 222, pp. 190-200. Date of Electronic Publication: 2018 Apr 25.
DOI: 10.1016/j.jep.2018.04.019
Abstrakt: Ethnopharmacological Relevance: The leaves and roots of Cissampelos sympodialis (Menispermaceae) are used by indian tribes and in folk medicine to treat genitourinary infections, inflammation, asthma and gastrointestinal disorders.
Material and Methods: The standardized ethanolic extract (Cs-EtOHE) and alkaloids total fraction (Cs-TAF) obtained from aerial parts of C. sympodialis were evaluated in several models of acute gastric ulcers. The antisecretory and/or neutralizing mechanisms of the gastric acid secretion, cytoprotective, antioxidant and immunoregulatory mechanisms were also evaluated.
Results: Cs-EtOHE and Cs-TAF presented a reduction in gastric mucosa lesions against ethanol, NSAIDs, hypothermic restraint-stress and gastric juice containment induced ulcer models. This activity is related to alkaloids present in the extract, and involves the participation of sulfhydryl compounds, nitric oxide, K ATP channels, prostaglandins, decreased levels of IL-1β and TNF-α and increased levels of GSH and IL-10.
Conclusion: The data indicate gastroprotective activity, due to the participation of the cytoprotective, antioxidant and immunoregulatory mechanisms.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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