Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies.
| Autor: | Wan Jamaludin WF; Universiti Kebangsaan Malaysia Medical Centre, Cell Therapy Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia. sfadilah@ppukm.ukm.edu.my., Mohamad Yusoff F, Ismail NA, Mohd Idris MR, Palaniappan S, Ng CKK, Abdullah N, Zaider SZA, Abdul Wahid SFS |
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| Jazyk: | angličtina |
| Zdroj: | The Malaysian journal of pathology [Malays J Pathol] 2018 Apr; Vol. 40 (1), pp. 61-67. |
| Abstrakt: | Introduction: Immunosuppressive state due to haematological malignancies and chemotherapy may cause disruption to wound healing despite optimum conventional treatment and standard wound dressing. Non-healing wounds are predisposed to infection whereas chemotherapy dose reductions or interruptions are associated with poor survival. Background: Mononuclear cells contain progenitor cells including haematopoietic and mesenchymal stem cells, endothelial progenitor cells and fibroblasts which facilitate wound healing through cytokines, growth factor secretions, cell-cell interactions and provision of extracellular matrix scaffolding. Clinical applications of autologous mononuclear cells therapy in wound healing in non-malignant patients with critical limb ischaemia have been reported with remarkable outcome. Methods: We report three patients with haematological malignancies undergoing chemotherapy, who received autologous mononuclear cells implantation to treat non-healing wound after optimum conventional wound care. The sources of mononuclear cells (MNC) were from bone marrow (BM), peripheral blood (PB) and mobilised PB cells (mPB-MNC) using granulocyte colony stimulating factor (G-CSF). The cells were directly implanted into wound and below epidermis. Wound sizes and adverse effects from implantation were assessed at regular intervals. Results: All patients achieved wound healing within three months following autologous mononuclear cells implantation. No implantation adverse effects were observed. Conclusions: Autologous mononuclear cells therapy is a feasible alternative to conventional wound care to promote complete healing in non-healing wounds compounded by morbid factors such as haematological malignancies, chemotherapy, diabetes mellitus (DM), infections and prolonged immobility. |
| Databáze: | MEDLINE |
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