The accuracy of chemotherapy ascertainment among colorectal cancer patients in the surveillance, epidemiology, and end results registry program.

Autor: Healy MA; Center for Healthcare Outcomes & Policy, University of Michigan, 300 North Ingalls, Rm 3A22, Ann Arbor, MI, 48105, USA., Morris AM; Center for Healthcare Outcomes & Policy, University of Michigan, 300 North Ingalls, Rm 3A22, Ann Arbor, MI, 48105, USA.; Institute for Healthcare Policy and Innovation, University of Michigan, 300 North Ingalls, Rm 3A22, Ann Arbor, MI, 48105, USA., Abrahamse P; Institute for Healthcare Policy and Innovation, University of Michigan, 300 North Ingalls, Rm 3A22, Ann Arbor, MI, 48105, USA., Ward KC; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Kato I; Department of Pathology, Wayne State University, Detroit, MI, USA., Veenstra CM; Center for Healthcare Outcomes & Policy, University of Michigan, 300 North Ingalls, Rm 3A22, Ann Arbor, MI, 48105, USA. cveenstr@med.umich.edu.; Institute for Healthcare Policy and Innovation, University of Michigan, 300 North Ingalls, Rm 3A22, Ann Arbor, MI, 48105, USA. cveenstr@med.umich.edu.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2018 Apr 27; Vol. 18 (1), pp. 481. Date of Electronic Publication: 2018 Apr 27.
DOI: 10.1186/s12885-018-4405-7
Abstrakt: Background: Surveillance, Epidemiology, and End Results (SEER) public research database does not include chemotherapy data due to concerns for incomplete ascertainment. To compensate for perceived lack of data quality many researchers use SEER-Medicare linked data, limiting studies to persons over age 65. We sought to determine current SEER ascertainment of chemotherapy receipt in two relatively large SEER registries compared to patient-reported receipt and to assess patterns of under-ascertainment.
Methods: In 2011-14, we surveyed patients with Stage III colorectal cancer reported to the Georgia and Metropolitan Detroit SEER registries. 1301/1909 eligible patients responded (68% response rate). Survey responses regarding treatment and sociodemographic factors were merged with SEER data. We compared patient-reported chemotherapy receipt with SEER recorded chemotherapy receipt. We estimated multivariable regression models to assess associations of under-ascertainment in SEER.
Results: Eighty-five percent of patients reported chemotherapy receipt. Among those, 10% (n = 104) were under-ascertained in SEER (coded as not receiving chemotherapy). In unadjusted analyses, under-ascertainment was more common for older patients (11.8% age 76+ vs. < 9% for all other ages, p = 0.01) and varied with SEER registries (10.2% Detroit vs. 6.8% Georgia; p = 0.04). On multivariable analyses, chemotherapy under-ascertainment did not vary significantly by any patient attributes.
Conclusion: We found a 10% rate of under-ascertainment of adjuvant chemotherapy for resected, stage III colorectal cancer in two SEER registries. Chemotherapy under-ascertainment did not disproportionately affect any patient subgroups. Use of SEER data from select registries is an important resource for researchers investigating contemporary chemotherapy receipt and outcomes.
Databáze: MEDLINE
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