Higher 5-HT 1A autoreceptor binding as an endophenotype for major depressive disorder identified in high risk offspring - A pilot study.

Autor: Milak MS; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States. Electronic address: mm2354@cumc.columbia.edu., Pantazatos S; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Rashid R; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Zanderigo F; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., DeLorenzo C; Department of Psychiatry, Perelman School of Medicine, United States., Hesselgrave N; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Ogden RT; Department of Biostatistics, Columbia University, Mailman School of Public Health, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Oquendo MA; Department of Psychiatry, Perelman School of Medicine, United States., Mulhern ST; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Miller JM; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Burke AK; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States., Parsey RV; Department of Psychiatry, Stony Brook Medicine, Stony Brook, New York, United States., Mann JJ; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Department of Radiology, Columbia University, College of Physicians and Surgeons, New York, NY, United States; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2018 Jun 30; Vol. 276, pp. 15-23. Date of Electronic Publication: 2018 Apr 13.
DOI: 10.1016/j.pscychresns.2018.04.002
Abstrakt: Higher serotonin-1A (5-HT 1A ) receptor binding potential (BP F ) has been found in major depressive disorder (MDD) during and between major depressive episodes. We investigated whether higher 5-HT 1A binding is a biologic trait transmitted to healthy high risk (HR) offspring of MDD probands. Data were collected contemporaneously from: nine HR, 30 depressed not-recently medicated (NRM) MDD, 18 remitted NRM MDD, 51 healthy volunteer (HV) subjects. Subjects underwent positron emission tomography (PET) using [ 11 C]WAY100635 to quantify 5-HT 1A BP F , estimated using metabolite, free fraction-corrected arterial input function and cerebellar white matter as reference region. Multivoxel pattern analyses (MVPA) of PET data evaluated group status classification of individuals. When tested across 13 regions of interest, an effect of diagnosis is found on BP F which remains significant after correction for sex, age, injected mass and dose: HR have higher BP F than HV (84.3% higher in midbrain raphe, 40.8% higher in hippocampus, mean BP F across all 13 brain regions is 49.9% ± 11.8% higher). Voxel-level BP F maps distinguish HR vs. HV. Elevated 5-HT 1A BP F appears to be a familially transmitted trait abnormality. Future studies are needed to replicate this finding in a larger cohort and demonstrate the link to the familial transmission of mood disorders.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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