Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention.

Autor:	Ribeiro MR; Graduate Program in Nutrition Sciences, (Centro de Ciências da Saúde-CCS), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Lima RPA; Graduate Program in Nutrition Sciences, (Centro de Ciências da Saúde-CCS), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Lisboa JVC; Graduate Program in Nutrition Sciences, (Centro de Ciências da Saúde-CCS), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Chaves TR; Graduate Program in Nutrition Sciences, (Centro de Ciências da Saúde-CCS), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Luna RCP; Graduate Program in Nutrition Sciences, (Centro de Ciências da Saúde-CCS), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., do Nascimento RAF; Graduate Program in Molecular and Human Biology, Center of Exact and Natural Sciences (Centro de Ciências Exatas e da Natureza-CCEN), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., de Oliveira Y; Graduate Program in Nutrition Sciences, (Centro de Ciências da Saúde-CCS), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Persuhn DC; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Sérgio da Silva A; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Gonçalves MDCR; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Ferreira FELL; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Lima RT; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., da Silva Diniz A; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., de Almeida ATC; Department of Economics, Center of Applied Social Sciences (Centro de Ciências Sociais Aplicadas-CCSA), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., de Moraes RM; Graduate Program in Health Decision Models, Center of Exact and Natural Sciences (Centro de Ciências Exatas e da Natureza-CCEN), Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil., Verly Junior E; Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro (Universidade Estadual do Rio de Janeiro-UERJ), Rio de Janeiro, Brazil., Costa MJC; Department of Nutrition, Federal University of Paraiba (Universidade Federal da Paraíba-UFPB), João Pessoa, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of the American College of Nutrition [J Am Coll Nutr] 2018 Nov-Dec; Vol. 37 (8), pp. 677-684. Date of Electronic Publication: 2018 Apr 27.
DOI:	10.1080/07315724.2018.1460224
Abstrakt:	The C677T polymorphism of the methylenetetrahydrofolate reductase gene ( MTHFR ) is related to folate metabolism and can alter the levels of biochemical markers. Objective : Investigate the influence of the MTHFR C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity. Methods : Forty-eight adult women with overweight or obesity were subjected to a 24-hour dietary recall, anthropometric measurements, biochemical analysis, and genotyping of the MTHFR C677T polymorphism. They were allocated by convenience sampling to 2 groups, which received 300 g of folate-rich vegetables containing 191 µg/d (Group 1) ( n = 24) or 95 µg/d (Group 2) ( n = 24) of folate for 8 weeks. Results : The dietary intervention increased the serum folic acid levels in the 2 analyzed groups. The intervention with 191 µg/d of folate led to relevant results in terms of homocysteine levels ( p = 0.0005) and total antioxidant capacity ( p = 0.0261); the effect was larger among carriers of the TT genotype. Conclusions : The study demonstrated the beneficial effect of folate intake in terms of a TAC elevation for the CC and TT genotypes of the MTHFR C677T polymorphism, an increase in folic acid levels for all genotypes, and a reduction in the Hcy levels for the TT genotype in response to an intervention consisting of an intake of 191 µg/d of folate supplied by vegetables.
Databáze:	MEDLINE
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