Papulopustular Rosacea: Response to Treatment with Oral Azithromycin.

Autor: Lova Navarro M; Servicio de Dermatología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España. Electronic address: lovamiguel@gmail.com., Sánchez-Pedreño Guillen P; Servicio de Dermatología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España., Victoria Martínez AM; Servicio de Dermatología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España., Martínez Menchón T; Servicio de Dermatología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España., Corbalán Vélez R; Servicio de Dermatología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España., Frías Iniesta J; Servicio de Dermatología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España.
Jazyk: English; Spanish; Castilian
Zdroj: Actas dermo-sifiliograficas [Actas Dermosifiliogr (Engl Ed)] 2018 Jul - Aug; Vol. 109 (6), pp. 529-535. Date of Electronic Publication: 2018 Apr 23.
DOI: 10.1016/j.ad.2018.02.009
Abstrakt: Introduction: Oral tetracyclines and topical antibiotics have been used to treat papulopustular rosacea (PPR) for years, but it is not uncommon to find patients who do not respond to this standard treatment. In such refractory cases, oral azithromycin has proven to be an effective option.
Material and Method: We conducted a prospective pilot study of 16 patients with PPR who were treated with oral azithromycin after a lack of response to oral doxycycline and metronidazole gel. At the first visit, the patients were assessed for baseline severity of PPR on a 4-point clinical scale and started on oral azithromycin. At the second visit, response to treatment in terms of improvement from baseline was evaluated on a 3-point scale. Patients were then scheduled for follow-up visits every 12 weeks to assess long-term effectiveness.
Results: All 16 patients experienced an improvement in their PPR following treatment with oral azithromycin. Eight weeks after completion of treatment, 14 patients (87.5%) showed complete or almost complete recovery (slight or no residual redness and complete clearance of papules and pustules). Only 2 patients experienced a new episode of inflammatory PPR lesions during follow-up.
Conclusions: The findings of this pilot study suggest that oral azithromycin could be a very effective short-term and long-term treatment for RPP resistant to conventional treatment.
(Copyright © 2018 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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