Red meat and processed meat intake and risk for cutaneous melanoma in white women and men: Two prospective cohort studies.

Autor: Yen H; Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Dermatology, Chang Gung Memorial Hospital Linkou and Taipei Branch, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Li WQ; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island., Dhana A; Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Dermatology, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa., Li T; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Qureshi A; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Cho E; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: eunyoung_cho@brown.edu.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2018 Aug; Vol. 79 (2), pp. 252-257.e6. Date of Electronic Publication: 2018 Apr 24.
DOI: 10.1016/j.jaad.2018.04.036
Abstrakt: Background: Red and processed meat consumption has been associated with increased risk for several cancers, but the association with cutaneous melanoma risk has been inconclusive.
Objective: To investigate the association between red and processed meat intake and melanoma risk.
Methods: Dietary information was assessed by using food frequency questionnaires in 2 prospective cohorts: 75,263 women from the Nurses' Health Study (1984-2010) and 48,523 men from the Health Professionals Follow-up Study (1986-2010). Melanoma cases were confirmed by reviewing pathology records. Pooled multivariable hazard ratios and 95% confidence intervals were estimated by using Cox proportional hazards models.
Results: A total of 679 female and 639 male melanoma cases were documented during follow-up. Red and processed meat intake was inversely associated with melanoma risk (P = .002 for trend); the pooled hazard ratios (95% confidence intervals) of the 2 cohorts were 1.00 (reference), 1.00 (0.87-1.14), 0.98 (0.86-1.13), 0.89 (0.77-1.02), and 0.81 (0.70-0.95) for increasing quintiles of intake.
Limitations: Findings might have limited generalizability, considering that the cohorts were limited to white health professionals.
Conclusion: Red and processed meat intake was inversely associated with melanoma risk in these 2 cohorts.
(Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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