| Autor: |
Sims JE; Immunex Corporation, Seattle, WA 98101., March CJ, Cosman D, Widmer MB, MacDonald HR, McMahan CJ, Grubin CE, Wignall JM, Jackson JL, Call SM, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1988 Jul 29; Vol. 241 (4865), pp. 585-9. |
| DOI: |
10.1126/science.2969618 |
| Abstrakt: |
Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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