Curcumin-loaded graphene oxide flakes as an effective antibacterial system against methicillin-resistant Staphylococcus aureus .

Autor:	Bugli F; Microbiology Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Cacaci M; Microbiology Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Palmieri V; Physics Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.; Institute for Complex Systems, National Research Council (ISC-CNR), Via dei Taurini 19, 00185 Rome, Italy., Di Santo R; Physics Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Torelli R; Microbiology Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Ciasca G; Physics Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Di Vito M; Microbiology Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.; Dipartimento Scienze Agrarie Università di Bologna Alma Mater Studorium, Bologna, Italy., Vitali A; CNR-ICRM, c/o Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Conti C; CNR-ICRM, c/o Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Sanguinetti M; Microbiology Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., De Spirito M; Physics Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy., Papi M; Physics Institute, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
Jazyk:	angličtina
Zdroj:	Interface focus [Interface Focus] 2018 Jun 06; Vol. 8 (3), pp. 20170059. Date of Electronic Publication: 2018 Apr 20.
DOI:	10.1098/rsfs.2017.0059
Abstrakt:	Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for serious hospital infections worldwide and represents a global public health problem. Curcumin, the major constituent of turmeric, is effective against MRSA but only at cytotoxic concentrations or in combination with antibiotics. The major issue in curcumin-based therapies is the poor solubility of this hydrophobic compound and the cytotoxicity at high doses. In this paper, we describe the efficacy of a composite nanoparticle made of curcumin (CU) and graphene oxide (GO), hereafter GOCU, in MRSA infection treatment. GO is a nanomaterial with a large surface area and high drug-loading capacity. GO has also antibacterial properties due mainly to a mechanical cutting of the bacterial membranes. For this physical mechanism of action, microorganisms are unlikely to develop resistance against this nanomaterial. In this work, we report the capacity of GO to support and stabilize curcumin molecules in a water environment and we demonstrate the efficacy of GOCU against MRSA at a concentration below 2 µg ml -1 . Further, GOCU displays low toxicity on fibroblasts cells and avoids haemolysis of red blood cells. Our results indicate that GOCU is a promising nanomaterial against antibiotic-resistant MRSA. Competing Interests: We declare we have no competing interests.
Databáze:	MEDLINE
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