Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma.

Autor:	De-Paula CR; Faculdade Ciências Médicas - Minas Gerais, Belo Horizonte, MG, Brazil., Magalhães GS; Faculdade Ciências Médicas - Minas Gerais, Belo Horizonte, MG, Brazil., Jentzsch NS; Faculdade Ciências Médicas - Minas Gerais, Belo Horizonte, MG, Brazil., Botelho CF; Faculdade Ciências Médicas - Minas Gerais, Belo Horizonte, MG, Brazil., Mota CCC; Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Murça TM; Universidade Salgado de Oliveira, Belo Horizonte, MG, Brazil., Ramalho LFC; Unidade de Referência Secundária Saudade, Prefeitura de Belo Horizonte, Belo Horizonte, MG, Brazil., Tan TC; Westmead Hospital, Faculty of Medicine, University of Sydney, Sidney, Australia., Capuruço CAB; Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Rodrigues-Machado MDG; Faculdade Ciências Médicas - Minas Gerais, Belo Horizonte, MG, Brazil.
Jazyk:	Portuguese; English
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2018 Mar; Vol. 110 (3), pp. 231-239.
DOI:	10.5935/abc.20180052
Abstrakt:	Background: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined. Objectives: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls. Methods: Eighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study. Echocardiography parameters were evaluated using conventional and tissue Doppler imaging (TDI). Results: Although pulmonary acceleration time (PAT) and pulmonary artery systolic pressure (PASP) were within normal limits, these parameters differed significantly between the control and asthmatic groups. PAT was lower (p < 0.0001) and PASP (p < 0.0002) was higher in the asthma group (114.3 ± 3.70 ms and 25.40 ± 0.54 mmHg) than the control group (135.30 ± 2.28 ms and 22.22 ± 0.40 mmHg). The asthmatic group had significantly lower early diastolic myocardial velocity (E', p = 0.0047) and lower E' to late (E'/A', p = 0.0017) (13.75 ± 0.53 cm/s and 1.70 ± 0.09, respectively) compared with control group (15.71 ± 0.34 cm/s and 2.12 ± 0.08, respectively) at tricuspid valve. In the lateral mitral valve tissue Doppler, the asthmatic group had lower E' compared with control group (p = 0.0466; 13.27 ± 0.43 cm/s and 14.32 ± 0.25 cm/s, respectively), but there was no statistic difference in the E'/A' ratio (p = 0.1161). Right isovolumetric relaxation time was higher (p = 0.0007) in asthmatic (57.15 ± 0.97 ms) than the control group (52.28 ± 0.87 ms), reflecting global myocardial dysfunction. The right and left myocardial performance indexes were significantly higher in the asthmatic (0.43 ± 0.01 and 0.37 ± 0.01, respectively) compared with control group (0.40 ± 0.01 and 0.34 ± 0.01, respectively) (p = 0.0383 and p = 0.0059, respectively). Physical activity level, and distance travelled on the six-minute walk test were similar in both groups. Conclusion: Changes in echocardiographic parameters, evaluated by conventional and TDI, were observed in mild-to-moderate asthma patients even with normal functional exercise capacity and baseline physical activity level. Our results suggest that the echocardiogram may be useful for the early detection and evoluation of asthma-induced cardiac changes.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu