Induction of Skin Allograft Transplantation Tolerance in Mice Using Human Adipose Derived Stromal Cells.

Autor:	Foster AD; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA.; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Clark N; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA., Davis TA; Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA. thomas.davis@usuhs.edu.; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. thomas.davis@usuhs.edu.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1773, pp. 73-91.
DOI:	10.1007/978-1-4939-7799-4_7
Abstrakt:	Murine models of allograft transplantation are valuable for understanding the immunological mechanisms of allograft acceptance and rejection, the evaluation of immunosuppressive drugs and strategies, and the restoration of functional defects. Herein, we describe methods to create a skin murine allograft surgical model and how to administer adipose-derived stromal cells (ASC) with limited numbers of donor bone marrow to create stable multilineage donor cell chimerism and indefinite immunological tolerance.
Databáze:	MEDLINE
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