Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor.

Autor: da Cunha Moraes G; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Vitoretti LB; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., de Brito AA; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Alves CE; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., de Oliveira NCR; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Dos Santos Dias A; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José dos Campos, SP, Brazil., Matos YST; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Oliveira-Junior MC; Experimental Cardiorespiratory Physiology Laboratory, Master's Degree and PhD Program in Rehabilitation Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Oliveira LVF; Experimental Cardiorespiratory Physiology Laboratory, Master's Degree and PhD Program in Rehabilitation Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., da Palma RK; Experimental Cardiorespiratory Physiology Laboratory, Master's Degree and PhD Program in Rehabilitation Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Candeo LC; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Lino-Dos-Santos-Franco A; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Horliana ACRT; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil., Gimenes Júnior JA; Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, Department of Surgery, University of California San Diego (UCSD) Health Sciences, San Diego, CA, USA., Aimbire F; Institute of Science and Technology, Federal University of São Paulo (UNIFESP), Sao José dos Campos, SP, Brazil., Vieira RP; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José dos Campos, SP, Brazil.; Post-graduation Program in Bioengineering, Universidade Brasil, São Paulo, SP, Brazil.; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil., Ligeiro-de-Oliveira AP; Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2018 Mar 04; Vol. 2018, pp. 6798238. Date of Electronic Publication: 2018 Mar 04 (Print Publication: 2018).
DOI: 10.1155/2018/6798238
Abstrakt: Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm 2 ) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1 β , IL-6, and TNF- α in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.
Databáze: MEDLINE
Externí odkaz: