The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis.

Autor: Rosito LPS; Hospital of Clinics of Porto Alegre and Department of Ophthalmology and Otorhinolaryngology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2400, Porto Alegre, RS, Brazil., Sperling N; Weill Cornell Medical College, New York, NY, USA., Teixeira AR; Hospital de Clínicas de Porto Alegre and Universidade Federal do Rio Grande do Sul, Department of Health and Human Communication, Rua Ramiro Barcelos 2777, Room 315, Anexo I da Saúde, Porto Alegre, RS, Brazil., Selaimen FA; Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre, RS, Brazil., da Costa SS; Hospital of Clinics of Porto Alegre and Department of Ophthalmology and Otorhinolaryngology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2400, Porto Alegre, RS, Brazil.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2018 Feb 21; Vol. 2018, pp. 9817123. Date of Electronic Publication: 2018 Feb 21 (Print Publication: 2018).
DOI: 10.1155/2018/9817123
Abstrakt: Objective: To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE.
Methods: Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM perforations according to signs of previous TM retraction.
Results: TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%; p < 0.0001).
Conclusion: Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma pathogenesis.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje