Local staging with multiparametric MRI in daily clinical practice: diagnostic accuracy and evaluation of a radiologic learning curve.

Autor: Jansen BHE; VU University Medical Center, Amsterdam, The Netherlands. bh.jansen@vumc.nl., Oudshoorn FHK; VU University Medical Center, Amsterdam, The Netherlands., Tijans AM; VU University Medical Center, Amsterdam, The Netherlands., Yska MJ; Maasstad Ziekenhuis, Rotterdam, The Netherlands., Lont AP; Meander Medisch Centrum, Amersfoort, The Netherlands., Collette ERP; Maasstad Ziekenhuis, Rotterdam, The Netherlands., Nieuwenhuijzen JA; VU University Medical Center, Amsterdam, The Netherlands., Vis AN; VU University Medical Center, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: World journal of urology [World J Urol] 2018 Sep; Vol. 36 (9), pp. 1409-1415. Date of Electronic Publication: 2018 Apr 21.
DOI: 10.1007/s00345-018-2295-6
Abstrakt: Purpose: To estimate the diagnostic accuracy of multiparametric MRI (mpMRI) for the detection of locally advanced prostate cancer (T-stage 3-4) prior to radical prostatectomy, in a multicenter cohort representing daily clinical practice. In addition, the radiologic learning curve for the detection of locally advanced disease is evaluated.
Methods: Preoperative mpMRI findings of 430 patients (2012-2016) were compared to pathology results following radical prostatectomy. The diagnostic accuracy (sensitivity, specificity, PPV, and NPV) for the detection of locally advanced disease was calculated and compared for all years separately, to evaluate the presence of a radiological learning curve.
Results: Of all 137 patients with locally advanced disease, 62 patients were preoperatively detected with mpMRI [sensitivity 45.3% (95% CI 36.9-53.6%), specificity 75.8% (CI 70.9-80.7%), PPV 46.6% (CI 38.1-55.1%), and NPV 74.7% (CI 69.8-79.7%)]. The diagnostic accuracy did not improve significantly over time (sensitivity p = 0.12; specificity p = 0.57).
Conclusions: In daily clinical practice, the diagnostic accuracy of mpMRI for the detection of locally advanced prostate cancer remains limited. It, therefore, seems questionable whether mpMRI is adequate to guide preoperative decision-making. No significant radiologic learning curve for the detection of locally advance disease was observed.
Databáze: MEDLINE
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