What podoplanin tells us about cells with telopodes.

Autor: Manta L; Faculty of Medicine,'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania; Department of Gynaecology and Obstetrics, 'Gh. Polizu' Maternity, 'Alfred Rusescu' Mother and Child Care Institute, Bucharest, Romania., Rusu MC; Division of Anatomy, Faculty of Dental Medicine, 'Carol Davila' University of Medicine and Pharmacy, 8 Eroilor Sanitari Blvd., RO-050474, Bucharest, Romania. Electronic address: mugurel.rusu@umfcd.ro., Pop F; Division of Pathologic Anatomy, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania; MEDCENTER - Center of Excellence in Laboratory Medicine and Pathology, Romania.
Jazyk: angličtina
Zdroj: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft [Ann Anat] 2018 Jul; Vol. 218, pp. 124-128. Date of Electronic Publication: 2018 Apr 18.
DOI: 10.1016/j.aanat.2018.04.001
Abstrakt: Telocytes (TCs) are stromal cells with telopodes, which represent long, thin, moniliform cell processes; however, this morphological feature alone is insufficient to define a cell type. Specific markers of lymphatic endothelial cells (LECs), such as Prox-1, podoplanin (D2-40) or LYVE-1, are not usually tested in TCs. We thus aimed at performing a study in light microscopy to evaluate whether or not LECs could be mistaken for TCs. Therefore we used CD34, α-smooth muscle actin and D2-40 for an immunohistochemical study on archived paraffin-embedded samples of uterine leiomyoma. Lymphatic vessels were identified by the expression of D2-40, but on the microscopic slides, false spindle-shaped TCs appearances either corresponded to collapsed lymphatic lumina or were determined by grazing longitudinal cuts of lymphatics. It is therefore mandatory to check the expression of lymphatic markers in telocyte-like cells and, moreover, to carefully examine the bidimensional cuts in order to avoid false results.
(Copyright © 2018 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: