Antibacterial Indole Alkaloids with Complex Heterocycles from Voacanga africana.

Autor:	Ding CF; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.; Graduate University of the Chinese Academy of Sciences , Beijing 100049 , People's Republic of China., Ma HX; State Key Laboratory of Respiratory Disease , Guangzhou Medical University , Guangzhou 510120 , People's Republic of China., Yang J; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China., Qin XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China., Njateng GSS; Department of Biochemistry, Faculty of Science , University of Dschang , P.O. Box 67, Dschang , Cameroon., Yu HF; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.; Graduate University of the Chinese Academy of Sciences , Beijing 100049 , People's Republic of China., Wei X; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.; Graduate University of the Chinese Academy of Sciences , Beijing 100049 , People's Republic of China., Liu YP; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China., Huang WY; State Key Laboratory of Respiratory Disease , Guangzhou Medical University , Guangzhou 510120 , People's Republic of China., Yang ZF; State Key Laboratory of Respiratory Disease , Guangzhou Medical University , Guangzhou 510120 , People's Republic of China., Wang XH; State Key Laboratory of Respiratory Disease , Guangzhou Medical University , Guangzhou 510120 , People's Republic of China., Luo XD; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.; State Key Laboratory of Respiratory Disease , Guangzhou Medical University , Guangzhou 510120 , People's Republic of China.
Jazyk:	angličtina
Zdroj:	Organic letters [Org Lett] 2018 May 04; Vol. 20 (9), pp. 2702-2706. Date of Electronic Publication: 2018 Apr 20.
DOI:	10.1021/acs.orglett.8b00913
Abstrakt:	Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a common precursor, 19- epi-voacristine. Both compounds exhibited potent activity against Staphylococcus aureus and Salmonella typhi, and their activities were superior to those of the well-known antibacterial drugs berberine and fibrauretine.
Databáze:	MEDLINE
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