Electroconvulsive seizures influence dendritic spine morphology and BDNF expression in a neuroendocrine model of depression.

Autor: Maynard KR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, United States., Hobbs JW; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, United States., Rajpurohit SK; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, United States., Martinowich K; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, United States; Departments of Neuroscience, Psychiatry and Behavioral Sciences, Johns Hopkins Medical School, Baltimore, MD, 21205, United States. Electronic address: Keri.martinowich@libd.org.
Jazyk: angličtina
Zdroj: Brain stimulation [Brain Stimul] 2018 Jul - Aug; Vol. 11 (4), pp. 856-859. Date of Electronic Publication: 2018 Apr 06.
DOI: 10.1016/j.brs.2018.04.003
Abstrakt: Background: Electroconvulsive therapy (ECT) is a rapid and effective treatment for major depressive disorder. Chronic stress-induced depression causes dendrite atrophy and deficiencies in brain-derived neurotrophic factor (BDNF), which are reversed by anti-depressant drugs. Electroconvulsive seizures (ECS), an animal model of ECT, robustly increase BDNF expression and stimulate dendritic outgrowth.
Objective: The present study aims to understand cellular and molecular plasticity mechanisms contributing to the efficacy of ECS following chronic stress-induced depression.
Methods: We quantify Bdnf transcript levels and dendritic spine density and morphology on cortical pyramidal neurons in mice exposed to vehicle or corticosterone and receiving either Sham or ECS treatment.
Results: ECS rescues corticosterone-induced defects in spine morphology and elevates Bdnf exon 1 and exon 4-containing transcripts in cortex.
Conclusions: Dendritic spine remodeling and induction of activity-induced BDNF in the cortex represent important cellular and molecular plasticity mechanisms underlying the efficacy of ECS for treatment of chronic stress-induced depression.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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